Americapox: The Missing Plague

Why didn't the Europeans get sick when they made contact with the American Indians?

Part 2:

Special Thanks:

Brian Mitchell, Danny Z, Joe Pantry, TheAlphaFactor, Duhilio Patiño, Benjamin Morrison, Jordan Melville, Mike Lanier, Martin, Steven Grimm, Alistair Forbes, Lou Rivellini, Tom Maher, Richard Jenkins, Chris Chapin,, سليمان العقل, Andres Villacres, Phil Gardner, Nevin Spoljaric, Tony DiLascio, Robert Kunz, Tod Kurt, Daniel Slater, Sam Pitts, Thomas J Miller Jr MD, Markus Persson, Wenhao Nie, Today I Found Out, Patricio Fons, Mark Govea


  • Scott Stein
    Scott Stein58 mínútum síðan

    Maybe the real plague was the friends we made on the way.

  • Connor R. Hunter
    Connor R. HunterDegi Síðan síðan

    But didn't we get a certain STI from llamas?

  • Gecko with a hat
    Gecko with a hat2 dögum síðan

    But just a little question… what about dogs. There we’re wolf in the americas and what about turkey’s

  • The Metatron
    The Metatron3 dögum síðan

    4:31 ... there's your "covid" 🙄

  • UsedPaperGames
    UsedPaperGames3 dögum síðan


  • tomw86
    tomw863 dögum síðan

    This hits a little different after 2020...

  • Sam Smith
    Sam Smith7 dögum síðan

    I’d argue you could theoretically built a civilisation from honey alone. It’d take a bit of effort and a bit of evolution (gut biome, enzymes adapted to sugars) and you could theoretically use honey as an energy source to fuel a civilisation along with fruit

  • Mihir patel
    Mihir patel8 dögum síðan

    5:26 "germs jumping species is extremely rare" Coronavirus : hold my mask boiiii

  • Countryballs Games and more
    Countryballs Games and more8 dögum síðan

    Can you make a mod which added phones?

  • Bruce Ismay
    Bruce Ismay10 dögum síðan

    I get you no std rule but Syphilis likely came from South America from the Columbian exchange and spread across the world from a battle in Europe with great power and was extremely common. It basically was a not quite as deadly but it was still pretty high.

  • Rob S
    Rob S10 dögum síðan

    Jared Diamond is a hack. Bison are easily domesticated. No more difficult than the ancestors of cows. Deer, elk, Caribou, ducks, geese, and many more north America animals are suitable for domestication.

  • Rob S

    Rob S

    8 dögum síðan

    @Belland _Dog with Bison you literally just have to build a fence and feed them. They are farmed in my home town. Northern European peoples managed the Caribou without using fencing. The American natives did not attempt domestication of animals and that is why they didn't accomplish it.

  • Belland _Dog

    Belland _Dog

    8 dögum síðan

    None of the animals are "easily" domesticated even with modern technology, besides the ducks and geese. And for Amerindians it was effectively impossible

  • Michael Watts
    Michael Watts11 dögum síðan

    The thing is, people who eat mostly fruits and vegetables don’t have nearly as much disease and inflammation as people who mostly eat things like pop tarts, cheetohs and sun chips. Processed food often have artificial colors, flavors and preservatives added to it. Have you seen Gut Reaction? It explains a lot

  • TrashDragon
    TrashDragon12 dögum síðan

    “Why can’t zebras be domesticated” *Listen here bud-*

  • Lagging
    Lagging14 dögum síðan

    I can tell you it is ever hard to keep llamas. I should know I have 8. Their a pain.

  • Cwazy_Coquitlamdd
    Cwazy_Coquitlamdd14 dögum síðan

    cgp grey goes tryhard to use the best shape: the hexagon.

  • Alex Benton
    Alex Benton14 dögum síðan

    "once you get a plague you can never get it again" *covid bursting down the door*: i beg to differ

  • Roman Nasuti

    Roman Nasuti

    14 dögum síðan

    With only one of these elements, it can still happen, but most will probably not get it twice. If neither, then neither. Problem is, I’m not sure COVID truly qualifies as a true plague: death or immunity is a commonality of plagues, and COVID is a disease that is really stretching the “deadly enough” requirement for a plague. Even measles, in a virgin population, is both more contagious and quite a few times deadlier, often enough to noticeably thin the population of a virgin civilization. It’s on this fact that I take the Hanlon’s Razor stance on COVID being man-made: if it was supposed to be a bio-weapon, it’s a *really* shitty one! Fast, unpredictable mutation and low initial contagion and fatality is a terrible mix for a bio weapon, as it won’t work fast and, when it does, it could very well kill you and your allies. A bioterrorist looking for a deadly, controllable viral weapon would start with Measles, find ways to make its SSPE pathway trigger more often (it’s a form of slow-burn encephalitis that is always fatal, untreatable, and a very rare complication of Measles infections), then engineer a fail safe that makes a specific protein combo (maybe a special version of CRISPR?) reliably deactivate it and stockpile that as an antidote. The SSPE change will likely necessitate a change in surface proteins anyways, so it’ll also be immune to the current measles vaccine but would be straightforward for the creator of said weapon strain to make some ahead of time in lieu of the antidote option.

  • Roman Nasuti

    Roman Nasuti

    14 dögum síðan

    Given two things: 1. Virgin population (never infected before) 2. Rapidly mutating disease Then yeah, multiple infections with slightly different versions of the same plague is not just possible but expected

  • that guy
    that guy14 dögum síðan

    A perfect place to grow: Wuhan

  • Theblocksmith
    Theblocksmith15 dögum síðan

    Even COVID came from the old world

  • Theblocksmith


    14 dögum síðan

    @Himallo Grey yes but it was still from the old world

  • Himallo Grey

    Himallo Grey

    14 dögum síðan

    The Bubonic plague was foreign to Europe at the time, spread by Genghis Khan.

  • knaz
    knaz16 dögum síðan

    But ... Wild sheep were in north America like 500,000 years ago. I am confused.

  • bbrake
    bbrake16 dögum síðan

    one more reason to move to (more) plant-based food systems, I guess. The other reason being environmental impacts and -increasingly- efficiency. Back then I guess forage and grazing made animal production the best we had, but now how many acres are being farmed to feed to animals? I love meat and am weak-willed, don't get me wrong, but on the whole? The world could do with a few BIG shifts that would solve a lot of problems.

  • Imonsay Ckimmay
    Imonsay Ckimmay17 dögum síðan

    What about Turkeys? They were American right?

  • Henrique Souto Maior Rezende
    Henrique Souto Maior Rezende17 dögum síðan

    This is basically a crossover of Civilization V and Plague Inc.

  • Formally Redacted
    Formally Redacted18 dögum síðan

    🧐 can't domesticate buffalo without modern tools. Elephants yes buffalo no.

  • kxats
    kxats19 dögum síðan

    A playground for plagues, I believe you meant to say a plagueground

  • ARavenInATrenchCoat
    ARavenInATrenchCoat19 dögum síðan


  • Alejandro Felix
    Alejandro Felix19 dögum síðan

    Yup, Europeans should build a big statue to smallpox, without it all America would have sent Europeans back home.

  • Jackson K
    Jackson K20 dögum síðan

    5:31 shiii we all winning the lottery now a days

  • Kholdilocks
    Kholdilocks20 dögum síðan

    Dogs a few times, cats a few times, sheep, pig, cow, goat, honeybee, silkworm, horse, camel, chicken, water buffalo, guinea pig (new world, too), llama, alpaca, ferret, duck, turkey, rabbit... Seems like there's a lot more than just twelve, no? Though most are still old world.

  • A50ftfall
    A50ftfall22 dögum síðan

    However the new world did bring one slightly significant disease and it is called Syphilis

  • ELane Rissler
    ELane Rissler23 dögum síðan

    The wet flood consistently scatter because breakfast obviously vanish across a blushing state. shaky, small april

  • DamagedBloon
    DamagedBloon24 dögum síðan

    so thats where covid-19 came from

  • Roasted foreskin is yummy

    Roasted foreskin is yummy

    21 degi síðan síðan


  • Emilio Fahr
    Emilio Fahr24 dögum síðan

    This video is quite old now but it does not appear to be the case that there were not large cities in the "new world". On the contrary, the size of some of the major cities may have exceeded that which could be found in the "old world".

  • David Sorto

    David Sorto

    10 dögum síðan

    Right but consider how many large cities there were in the Americas. V few when compared to the old world

  • Great Sage Equal To Heaven

    Great Sage Equal To Heaven

    15 dögum síðan

    He covers this, he says that the new world had big cities loke Teotihuacan.

  • TopDogJesse A Channel
    TopDogJesse A Channel24 dögum síðan

    The victorious bicycle structurally blush because scorpion proportionally flood towards a puzzled growth. statuesque, caring europe

  • Nicccckque
    Nicccckque25 dögum síðan

    if you're making jokes about how this "hits different" or "he predicted it", please watch the video. COVID is from China, not the US. The video is literally about why Americans didn't have a plague to spread to Europeans during eras such as the Columbian Exchange. It's not a prediction just because he mentioned plagues and pandemics, people.

  • Calmaressurgebat
    Calmaressurgebat26 dögum síðan

    Siphilus is from the Americas

  • Wesley Hov

    Wesley Hov

    26 dögum síðan

    It’s sexually transmitted disease though

  • ELane Rissler
    ELane Rissler27 dögum síðan

    The hateful design biophysically scream because scorpio gergely snore up a scintillating dinner. regular, abortive pimple

  • CMH17
    CMH1727 dögum síðan

    this didn't age too well

  • Brian Edwards
    Brian Edwards29 dögum síðan

    Aurochs weren't exactly sweet tempered Jerseys. Just saying.

  • Joe Mama
    Joe Mama29 dögum síðan

    Anyone else just thinking about covid the entire he was talking about how plagues start

  • Kerry Campbell
    Kerry CampbellMánuði síðan

    "Plagues come from animals." Covid origin confirmed!

  • alt acount
    alt acountMánuði síðan

    the old world had basically only 3 dosmesticatable animals: llama, monke and a hairless dog

  • Phone Account
    Phone AccountMánuði síðan

    I love how people try to blame the settlers for "spreading smallpox" when people literally didn't even know what germs were.

  • David Sorto

    David Sorto

    10 dögum síðan

    @Phone Account woah bro I don’t think you know what critical race theory is and the smallpox blanket idea isn’t a myth there are documents of settlers saying they were going to try it bc they knew it would kill the Indians

  • Phone Account

    Phone Account

    Mánuði síðan

    @I'm NoT NoT GaMeIaC MaNiAc The "smallpox blanket" lie is as big as the rest of the Critical Race Theory nonsense.

  • I'm NoT NoT GaMeIaC MaNiAc

    I'm NoT NoT GaMeIaC MaNiAc

    Mánuði síðan

    no one is blaming them for that

  • Real Human
    Real HumanMánuði síðan

    I guess we all won the worst lottery back in 2019.

  • AnthonyDK
    AnthonyDKMánuði síðan

    3:25 What is the source for this? I can't find anything about it and don't know what to even google for it

  • New_Indo776
    New_Indo776Mánuði síðan

    1:34 *what*

  • ymmij X

    ymmij X

    Mánuði síðan

    plagues use rapid vectors like water, air, or the like rather than slower but more persistent vectors like sexually transmitted diseases.

  • Skyman077
    Skyman077Mánuði síðan

    This is weird when you watch it in 2021

  • A.K. Salazar
    A.K. SalazarMánuði síðan

    Yep- let’s keep eating animals and cry when we get pandemics 😷 😂

  • ymmij X

    ymmij X

    14 dögum síðan

    @Himallo Grey that really has nothing to do with what's being discussed. that's distribution not creation.

  • Himallo Grey

    Himallo Grey

    14 dögum síðan

    There is a thing called "Contaminated Vegetables" where a sick person touches a veggie and everyone gets sick because they ate it.

  • ymmij X

    ymmij X

    Mánuði síðan

    it's really more about living in close proximity to animals. more the raising than the eating part but i get where you're coming from

  • NotFine


    Mánuði síðan

    Eating animals doesnt give diseases cause you know they're dead and cooked usually

  • Svoj Svojson
    Svoj SvojsonMánuði síðan

    3:48 Wee dye

  • Caleb Kallimanis
    Caleb KallimanisMánuði síðan

    Umm you forgot to mention though they had domesticated dogs in different forms

  • MrOsiz
    MrOsizMánuði síðan

    What about turkey?

  • ymmij X

    ymmij X

    Mánuði síðan

    i think he's doing the reductive and tossing ducks, chickens, and turkeys into the big fat bird bucket.

  • Somu Natarajan
    Somu NatarajanMánuði síðan

    Your are saying the future

  • Zaid Lacksalastname
    Zaid LacksalastnameMánuði síðan

    The ISsofts algorithm is bullying me rn

  • Adam Pugh
    Adam PughMánuði síðan

    The New World had wolves, right? Couldn't the Americans have domesticated dogs?

  • David Sorto

    David Sorto

    10 dögum síðan

    @Adam Pugh the Americans did domesticate many dogs and used them all the time. Unfortunately they were also all killed off the same way the Indians were

  • Adam Pugh

    Adam Pugh

    29 dögum síðan

    @ymmij X Okay, so the Americans didn't have time to domesticate the dogs. That makes sense.

  • ymmij X

    ymmij X

    Mánuði síðan

    oh yea totally... eventually. domesticating dogs happened so far back in human history it's likely it took a LONG time to stick.

  • I'm NoT NoT GaMeIaC MaNiAc

    I'm NoT NoT GaMeIaC MaNiAc

    Mánuði síðan

    wolves and dogs are not the same, and the wolves were hard to find aggressive and went in large packs

  • Collin Ingraham
    Collin IngrahamMánuði síðan

    You are forgetting alot of things such as . A hum. The fact that the "old world" was interconnected based on the fact that you could walk from China to Spain. Also there is the fact that the old world doesnt stem from a handful of families that all share the same ansestry. Also the old world had alot more people to start out with there for they had more people in the long run. Its like investing 20 usd from the time you are 18 compared to investing 100 usd when you are 40. In the long run 20 usd when you are 18 is going to garner you more money. The native Americans were literally a people group cut off from every other people group. Native groups are more closely related to each other than I am to someone from Basque Spain or than I am from someone from Egypt even though are people groups have had knowledge and trade with each other for thousands of years. Even the bronze age Mediterranean world would have spread every disease anyone had to every place in the old world. If someone had a disease in egypt it would have made its way to china. If someone had a disease in Labanon it would have ended up in England.

  • Face Octopus
    Face OctopusMánuði síðan

    According to the CDC, the origin of smallpox is unknown.

  • Menos Problemos
    Menos ProblemosMánuði síðan

    This was very more interesting that I thought it'd be. 😮 And I had already clicked on it out of interest!

  • Menos Problemos
    Menos ProblemosMánuði síðan

    Native American - The white man has forgotten what it is to be part of nature. The white man - Greetings! We bring plague from the nature we live with

  • Vinay Krishnan
    Vinay KrishnanMánuði síðan

    Conveniently shifting the blame to the Spanish?

  • LuskuBlusk


    Mánuði síðan

    I mean it was the Spanish that went over there in the first place. And don’t worry, he’s not attacking them and never even said they are the villian

  • webbgroup
    webbgroupMánuði síðan

    This was alright of an episode but certainly several tangents.

  • Face Octopus
    Face OctopusMánuði síðan

    Domestic dogs existed in the americas. When humans migrated to the americas they brought dogs with them. Chihuahuas are the descendants of those immigrants.

  • DomesticOnion
    DomesticOnionMánuði síðan

    This makes me wonder, Are there any diseases that originated specifically to infect humans?

  • Ok Boomer!
    Ok Boomer!Mánuði síðan

    America pox was syphilis.

  • drfd vvb
    drfd vvbMánuði síðan

    (Cough Cough ) SYPHILIS EXIST (Cough Cough)

  • Tem tem
    Tem temMánuði síðan

    Music scources please

  • Zahra Aziz
    Zahra AzizMánuði síðan


  • Seth Kunert
    Seth KunertMánuði síðan

    Hold up. Shouldnt we have super plagues that make the host relatively immortal then? Then it would probably wind up being assimilated to our physiollogy and an organ for its propogation developed. Like liver enymes... what if they started as competing phages to many of our parts

  • NoobExtortion
    NoobExtortionMánuði síðan

    I finished this video and then realized I'd watched it before.

  • Barbara
    BarbaraMánuði síðan

    It's 2021. Time to boost the algorithm for this video... (no idea how it got into my feed btw but I don't complain!)

  • A.M. The Shiny Johto Hunter
    A.M. The Shiny Johto HunterMánuði síðan

    You forgot Turkeys... last time I checked turkeys were from North America and were brought back to the world world, then went through the country of Turkey, where the perfected the domestication process... hence “bird of turkey”, then just turkey... wasn’t that another video from here?...

  • Ramón Correa
    Ramón CorreaMánuði síðan

    What about non flying birds?

  • Lin Grimm
    Lin GrimmMánuði síðan

    You point out llama in South America, and mention dogs role in livestock domestication in the Old World. Were there precontact dogs in the New World too?

  • AHappyRainCloud


    Mánuði síðan

    There were dogs in the new world but they were ridiculously small about the size of a modern day pomeranian or chihuahua

  • Felicity Chevalier
    Felicity ChevalierMánuði síðan

    3:47 wowww they're wearing masks!!!

  • icyblade21
    icyblade21Mánuði síðan

    uh oh

  • David Schaftenaar
    David SchaftenaarMánuði síðan

    The *New World (or more specifically: North America) had horses and camels* which coexisted for thousands of years with Native Americans. These animals actually evolved there and then came to the Old World via the landbridge across the Bering Strait, just like humans did in reverse. Horses aren't an invasive species to the America's: The Spanish simply reintroduced a native species that had been extirpated by Native Americans by the time they arrived. The New World not having domesticable animals is a false narrative, frankly.

  • Guy Person

    Guy Person

    Mánuði síðan

    Camels and horses went extinct in 11000 BCE, they were just learning to farm maize by that point. They were in no position to domesticate them. Also he never said they didn’t have domesticatable animals, just less of them, (llamas). So yeah, your pushing a false narrative buddy ;)

  • David Schaftenaar
    David SchaftenaarMánuði síðan

    There is one major exception though: Syphilis. It's the one seriously bad disease that was spread to Europe from the New World. It was no plague though, or at least not anything on par with Smalll Pox. I probably wouldn't have been here writing this if it had been.

  • vogonp 42
    vogonp 42Mánuði síðan

    This aged well...

  • painting humanoid
    painting humanoidMánuði síðan

    saying that buffalo were untameable compared to "cows" of which the ancestors were aurochs makes no sense. aurochs are estimated to have been just as tall and heavy as bison and also very aggressive. so why and how did people domesticate these extremely aggressive tanks with hooves and horns (also other similiar bovines like yak, arni, gaur and banteng, gaur being even bigger than aurochs or bison) but not bison? cgp avoids this question and never even mentions aurochs

  • Piccylo Daimajoou
    Piccylo DaimajoouMánuði síðan

    Also, corn time!

  • partya11night20
    partya11night20Mánuði síðan

    The new world has as many wolves as old world. People didn't domesticate dogs

  • Hritik Vijay
    Hritik VijayMánuði síðan

    and now we have bats

  • Misadique
    MisadiqueMánuði síðan


  • Lu Gan
    Lu GanMánuði síðan

    what about dogs from wolves? the chihuahua? or cats from bigger cats? this seems like the idea from guns germs and steel, but a confident voice doesn't mean its true and we may never know without a counterfactual. this theory of development ignores asian and their rice

  • P A
    P AMánuði síðan

    Guinea pigs had been domesticated in America as well as llamas.

  • Brough Cosgrove
    Brough CosgroveMánuði síðan

    3:46 A playground? Or a plague ground? 🤔

  • LK007
    LK007Mánuði síðan

    5:34 We won the lottery last year

  • dino nuggies guy
    dino nuggies guyMánuði síðan

    P2w and rng based game, 1/10, wouldn't reccomend unless you won 1000 lottery

  • Nick Lundin
    Nick LundinMánuði síðan

    The beautful painingts yessss

  • Aidcrazy Sol
    Aidcrazy SolMánuði síðan

    How would coron fit into this?

  • Gay As A Rainbow
    Gay As A RainbowMánuði síðan


  • TornadoHarry
    TornadoHarryMánuði síðan

    3:45 playground of plagues? More like plagueground

  • Schlugel
    SchlugelMánuði síðan


  • Juan Sarmiento
    Juan SarmientoMánuði síðan


  • Edgar Aldana
    Edgar AldanaMánuði síðan

    Ok, but why there were no pigs, cows and horses in America?

  • Jasper Paolo

    Jasper Paolo

    Mánuði síðan

    They’re native to Europe and Asia

  • fclp67
    fclp67Mánuði síðan

    New thumbnail dropped bois

  • plop plopp
    plop ploppMánuði síðan


  • Dorinel33
    Dorinel33Mánuði síðan

    Well, now it's not missing anymore...

  • KenTheTrul
    KenTheTrulMánuði síðan

    Fun fact. The species that predated horses originated in the new world, some migrated to the old world on the same land bridge humans used to cross over to the americas in the first place. Then the humans that migrated to the americas hunted pre-horses to extinction. So when Europeans brought horses to the Americas, they were just bringing them back to their ancestral homeland.

  • Graham Pritchard
    Graham PritchardMánuði síðan

    Chulls and Chickens.

  • Mynem Esjeff
    Mynem EsjeffMánuði síðan

    5:34 damn there was a big winner in China 2019

  • Takahashi
    TakahashiMánuði síðan

    10:16 hexagons are the bestagons